Direct Determination of Lipoprotein Particle Sizes and Concentrations by Ion Mobility Analysis
نویسندگان
چکیده
منابع مشابه
Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis.
BACKGROUND Current methods for measuring the concentrations of lipoprotein particles and their distributions in particle subpopulations are not standardized. We describe here and validate a new gas-phase differential electrophoretic macromolecular mobility-based method (ion mobility, or IM) for direct quantification of lipoprotein particles, from small, dense HDL to large, buoyant, very-low-den...
متن کاملConcerns regarding lipoprotein particle measurement by ion mobility analysis.
We read with interest the report by Caulfield et al. (1 ) describing a new method for measuring lipoprotein particle concentrations by ion mobility (IM) analysis. There is growing evidence that the LDL particle concentration, as assessed by apolipoprotein B (apo B) or nuclear magnetic resonance (NMR) measurements, is a better discriminator of cardiovascular risk than the LDL cholesterol concent...
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BACKGROUND We aimed to measure propofol concentrations in exhaled air with an ion mobility spectrometer coupled to a multicapillary column for pre-separation (MCC-IMS). In addition, we aimed to compare the values of these measurements with serum propofol concentrations, as determined by gas chromatography-mass spectrometry (GC-MS). METHODS Thirteen patients, ASA I or II, undergoing elective E...
متن کاملQuantification of HDL particle concentration by calibrated ion mobility analysis.
BACKGROUND It is critical to develop new metrics to determine whether HDL is cardioprotective in humans. One promising approach is HDL particle concentration (HDL-P), the size and concentration of HDL in plasma. However, the 2 methods currently used to determine HDL-P yield concentrations that differ >5-fold. We therefore developed and validated an improved approach to quantify HDL-P, termed ca...
متن کاملDirect Determination of Urinary Creatinine by Reactive-Thermal Desorption-Extractive Electrospray-Ion Mobility-Tandem Mass Spectrometry.
A direct, ambient ionization method has been developed for the determination of creatinine in urine that combines derivatization and thermal desorption with extractive electrospray ionization and ion mobility-mass spectrometry. The volatility of creatinine was enhanced by a rapid on-probe aqueous acylation reaction, using a custom-made thermal desorption probe, allowing thermal desorption and i...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2008
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2007.100586